Synthesis and antimitotic activity of alkoxy-substituted 1-aryl-3-(arylamino)alkenones

Synthesis and antimitotic activity of alkoxy-substituted 1-aryl-3-(arylamino)alkenones Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2015, Volume: 64, Number: 2, Pages: 439-444 Pages count : 6 DOI: 10.1007/s11172-015-0883-9

Authors

Samet A.V. ¹ , Zhuzhin V.Yu. ² , Semenova M.N. ³ , Semenov V.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
2	Higher Chemical College, Russian Academy of Sciences, Moscow, Russian Federation
3	N. K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russian Federation

Alkoxy-substituted 1-aryl-3-(arylamino)prop-2-en-1-ones and 1-aryl-3-(arylamino)but-2en-1-ones were synthesized by the addition of anilines to 1,3-dioxo derivatives or aryl ethynyl ketones. The cis-trans isomerism of these compounds was studied. Biological tests on a sea urchin embryo model showed that 1-aryl-3-(arylamino)prop-2-en-1-ones exhibit an antimitotic effect both via microtubule destabilization and through the action on other cellular targets. The antiproliferative activity of these compounds increases with an increase in the number of alkoxy substituents in 1-aryl ring, whereas the presence of one methoxy group in the para position proved to be optimal for the arylamino moiety.

Samet A.V. , Zhuzhin V.Y. , Semenova M.N. , Semenov V.V.
Synthesis and antimitotic activity of alkoxy-substituted 1-aryl-3-(arylamino)alkenones
Russian Chemical Bulletin. 2015. V.64. N2. P.439-444. DOI: 10.1007/s11172-015-0883-9 WOS Scopus OpenAlex

Web of science:	WOS:000363260900027
Scopus:	2-s2.0-84945175725
OpenAlex:	W2336872415

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