Реферат: Aspergillus fumigatus is a very common fungus with high pathogenic potential for immunosuppressed hospital patients. A. fumigatus galactomannan, being the part of its cell wall, is considered as a promising candidate for vaccine and diagnostic test-systems. In this article we report the convergent synthesis of pentasaccharide fragments of the galactomannan containing the β-(1→5)-linked galactofuranoside chain attached to O-3 or O-6 of a spacer-armed mannopyranoside residue. The synthesis of selectively protected galactofuranoside precursors has been performed using recently developed pyranoside-into-furanoside (PIF) rearrangement. For assembling the target galactomannan structures the [1 + 2 + 2]-scheme was applied. This strategy was shown to be highly efficient and can easily be extended to the synthesis of longer fragments of thegalactomannan.

Библиографическая ссылка: Argunov D.A. , Krylov V.B. , Nifantiev N.E.
Convergent synthesis of isomeric heterosaccharides related to the fragments of galactomannan from Aspergillus fumigatus
Organic & Biomolecular Chemistry. 2015. V.13. N11. P.3255-3267. DOI: 10.1039/c4ob02634a WOS Scopus OpenAlex

Идентификаторы БД:

≡ Web of science:	WOS:000351062700014
≡ Scopus:	2-s2.0-84924710204
≡ OpenAlex:	W1998119598

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