A Direct Approach to a 6-Hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine Library

A Direct Approach to a 6-Hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine Library Full article

Journal

Organic Letters
ISSN: 1523-7060 , E-ISSN: 1523-7052

Output data

Year: 2014, Volume: 16, Number: 2, Pages: 406-409 Pages count : 4 DOI: 10.1021/ol403308h

Authors

Palysaeva Nadezhda V ¹ , Kumpan Katerina P ¹ , Struchkova Marina I ¹ , Dalinger Igor L ¹ , Kormanov Aleksandr V ¹ , Aleksandrova Nataly S ¹ , Chernyshev Victor M ² , Pyreu Dmitrii F ³ , Suponitsky Kyrill Yu ⁴ , Sheremetev Aleksei B ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, RussianFederation
2	South-Russia State Technical University, Novocherkassk 346428, Russian Federation
3	Ivanovo State University, Ivanovo 153025, Russian Federation
4	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow 119991,Russian Federation

The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields.

Palysaeva N.V. , Kumpan K.P. , Struchkova M.I. , Dalinger I.L. , Kormanov A.V. , Aleksandrova N.S. , Chernyshev V.M. , Pyreu D.F. , Suponitsky K.Y. , Sheremetev A.B.
A Direct Approach to a 6-Hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine Library
Organic Letters. 2014. V.16. N2. P.406-409. DOI: 10.1021/ol403308h WOS Scopus OpenAlex

≡ Web of science:	WOS:000330098400021
≡ Scopus:	2-s2.0-84896799566
≡ OpenAlex:	W1979638328