Investigations into the structure–activity relationship in gemini QACs based on biphenyl and oxydiphenyl linker

Investigations into the structure–activity relationship in gemini QACs based on biphenyl and oxydiphenyl linker Full article

Journal

RSC Advances
ISSN: 2046-2069

Output data

Year: 2021, Volume: 11, Number: 6, Pages: 3429-3438 Pages count : 10 DOI: 10.1039/d0ra08900a

Authors

Vereshchagin Anatoly N. ¹ , Frolov Nikita A. ¹ , Konyuhova Valeria Yu ¹ , Kapelistaya Ekaterina A. ¹ , Hansford Karl A. ² , Egorov Mikhail P. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Procpekt, 119991 Moscow, Russia
2	Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia

Eighteen novel gemini quaternary ammonium compounds were synthesized to examine the effect of linker nature, aliphatic chain length and their relative position on antibacterial and antifungal activity. The synthesized compounds showed strong bacteriostatic activity against a panel of both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and two fungi. Some of these compounds exhibited a wider and more potent antimicrobial spectrum than commonly-used antiseptics, such as benzalkonium chloride (BAC), cetylpyridinium chloride (CPC), chlorhexidine digluconate (CHG) and octenidine dihydrochloride (OCT).

Vereshchagin A.N. , Frolov N.A. , Konyuhova V.Y. , Kapelistaya E.A. , Hansford K.A. , Egorov M.P.
Investigations into the structure–activity relationship in gemini QACs based on biphenyl and oxydiphenyl linker
RSC Advances. 2021. V.11. N6. P.3429-3438. DOI: 10.1039/d0ra08900a WOS Scopus OpenAlex

Web of science:	WOS:000611287900024
Scopus:	2-s2.0-85100018034
OpenAlex:	W3125263012

DB	Citing
OpenAlex	15
Scopus	10
Web of science	12