Synthesis of low-molecular-weight carbohydrate mimetics of heparin

Synthesis of low-molecular-weight carbohydrate mimetics of heparin Full article

Journal

Russian Journal of Bioorganic Chemistry
ISSN: 1608-330X , E-ISSN: 1573-9163

Output data

Year: 2011, Volume: 37, Number: 6, Pages: 672-706 Pages count : 35 DOI: 10.1134/s1068162011060100

Authors

Krylov V B ¹ , Ustiuzhanina N E ¹ , Nifant'ev N E ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia Federation

Natural glycosaminoglycan heparin remains the most commonly prescribed anticoagulant for hospitalized patients in modern medical practice. Unfortunately, its administration can be accompanied by a series of clinical side effects, including thrombocytopenia and bleeding. This determines the urgency of the development of alternative anticoagulant drugs based on modified heparin and polyanionic oligo- and polysaccharide derivatives, such as sulfated glucans, phosphomannans, and fucoidans. Here we review work on the synthesis of oligosaccharides corresponding to low-molecular-weight heparin fragments and their derivatives, as well as oligosaccharides imitating parts of heparin chains that are responsible for biological activity. The reviewed works were aimed at developing pharmaceutical preparations lacking the aforementioned disadvantages of heparin.

Krylov V.B. , Ustiuzhanina N.E. , Nifant'ev N.E.
Synthesis of low-molecular-weight carbohydrate mimetics of heparin
Russian Journal of Bioorganic Chemistry. 2011. V.37. N6. P.672-706. DOI: 10.1134/s1068162011060100 WOS Scopus OpenAlex

≡ Web of science:	WOS:000297344600002
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