Polyalkoxy Substituted 4H-Chromenes: Synthesis by Domino Reaction and Anticancer Activity Научная публикация
| Журнал |
ACS Combinatorial Science
ISSN: 2156-8952 , E-ISSN: 2156-8944 |
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| Вых. Данные | Год: 2012, Том: 14, Номер: 8, Страницы: 484-490 Страниц : 7 DOI: 10.1021/co300062e | ||||
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Реферат:
A series of 4H-chromenes containing various modifications in the ring B and polyalkoxy substituents in the ring E has been synthesized by Knoevenagel–Michael–hetero-Thorpe–Ziegler three-component domino reaction with the overall yield of 45–82%. The targeted molecules were evaluated in a phenotypic sea urchin embryo assay for antimitotic and microtubule destabilizing activity. The most active compounds 5{1,5} and 5{5,5} featured sesamol-derived ring B and m-methoxyphenyl or m-methoxymethylenedioxyphenyl ring E. Compounds 5{3,1}, 5{1,2}, 5{5,4}, 5{1,5}, and 5{5,5} exhibited strong cytotoxicity in the NCI60 human tumor cell line anticancer drug screen. Surprisingly, cell growth inhibition caused by these agents was more pronounced in the multidrug resistant NCI/ADR-RES cells than the parent OVCAR-8 cell line. The results suggest that polyalkoxy substited 4H-chromenes may prove to be advantageous for further design as anticancer agents.
Библиографическая ссылка:
Shestopalov A.M.
, Litvinov Y.M.
, Rodinovskaya L.A.
, Malyshev O.R.
, Semenova M.N.
, Semenov V.V.
Polyalkoxy Substituted 4H-Chromenes: Synthesis by Domino Reaction and Anticancer Activity
ACS Combinatorial Science. 2012. V.14. N8. P.484-490. DOI: 10.1021/co300062e WOS Scopus OpenAlex
Polyalkoxy Substituted 4H-Chromenes: Synthesis by Domino Reaction and Anticancer Activity
ACS Combinatorial Science. 2012. V.14. N8. P.484-490. DOI: 10.1021/co300062e WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000307422000008 |
| Scopus: | 2-s2.0-84865021356 |
| OpenAlex: | W2321885193 |