The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids

The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2011, Volume: 21, Number: 4, Pages: 183-185 Pages count : 3 DOI: 10.1016/j.mencom.2011.07.002

Authors

Sukhorukov Alexey Yu. ¹ , Andryushkevich Svetlana O. ² , Chilov Ghermes G. ¹ , Zeifman Alexey A. ¹ , Svitanko Igor V. ^2,1 , Ioffe Sema L. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	Higher Chemical College, Russian Academy of Sciences, 125047 Moscow, Russian Federation

Diastereoselective synthesis of 4-amino-7-hydroxyheptanoic acids 1, new GABA analogues, was performed involving reduction of C-3 functionalized 5,6-dihydro-4H-1,2-oxazines available from nitroethane. Molecular docking studies showed that amino acids of type 1 may bind to GABA transaminase, however, no inhibition was observed in the experiments with the enzyme.

Sukhorukov A.Y. , Andryushkevich S.O. , Chilov G.G. , Zeifman A.A. , Svitanko I.V. , Ioffe S.L.
The first synthesis and molecular docking studies of diastereomerically pure substituted 4-amino-7-hydroxyheptanoic acids
Mendeleev Communications. 2011. V.21. N4. P.183-185. DOI: 10.1016/j.mencom.2011.07.002 WOS Scopus OpenAlex

Web of science:	WOS:000294095500002
Scopus:	2-s2.0-79960807001
OpenAlex:	W1985064274

DB	Citing
OpenAlex	6
Scopus	5
Web of science	4