Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans

Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2013, Volume: 62, Number: 3, Pages: 836-843 Pages count : 8 DOI: 10.1007/s11172-013-0113-2

Authors

Kulikov A.S. ¹ , Epishina M.A. ¹ , Batog L.V. ¹ , Rozhkov V.Yu. ¹ , Makhova N.N. ¹ , Konyushkin L.D. ¹ , Semenova M.N. ² , Semenov V.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2	N. K. Kol´tsov Institute of Developmental Biology, Russian Academy of Sciences, 26 ul. Vavilova, 119334 Moscow, Russian Federation

A method of 3-amino-4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl)]furazan synthesis was optimized. Condensation of these compounds with 2,5-dimethoxytetrahydrofuran resulted in a series of previously unknown 4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl)]-3-(pyrrol-1-yl)furazans. All target compounds were evaluated for both antimitotic microtubule destabilizing effect in a phenotypic sea urchin embryo assay and cytotoxicity in a panel of 60 human cancer cell lines. Pyrrolyl derivatives of triazolylfurazans were determined as antiproliferative compounds. The most potent microtubule targeting compounds 7a and 7e are of interest for further trials as antineoplastic agents.

Kulikov A.S. , Epishina M.A. , Batog L.V. , Rozhkov V.Y. , Makhova N.N. , Konyushkin L.D. , Semenova M.N. , Semenov V.V.
Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans
Russian Chemical Bulletin. 2013. V.62. N3. P.836-843. DOI: 10.1007/s11172-013-0113-2 WOS Scopus OpenAlex

Web of science:	WOS:000329373400032
Scopus:	2-s2.0-84891799820
OpenAlex:	W2010536052

DB	Citing
OpenAlex	9
Scopus	9
Web of science	7