5-Arylmethylidene-2-iminothiazolidin-4-ones in the synthesis of novel dispiro-fused oxindolepyrrolidineiminothiazolidinones

5-Arylmethylidene-2-iminothiazolidin-4-ones in the synthesis of novel dispiro-fused oxindolepyrrolidineiminothiazolidinones Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2023, Volume: 59, Number: 4-5, Pages: 309-316 Pages count : 8 DOI: 10.1007/s10593-023-03198-8

Authors

Izmest’ev Alexei N. ¹ , Streltsov Andrey A. ^2,1 , Kravchenko Angelina N. ¹ , Gazieva Galina A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2	D. Mendeleev University of Chemical Technology of Russia, Moscow, Russia

A novel series of dispiro(indolinonepyrrolidineiminothiazolidinones) were synthesized by 1,3-dipolar cycloaddition of 5-arylmethylidene-2-iminothiazolidin-4-ones and azomethine ylides generated from N-alkylamino acids and isatin derivatives. A number of iminothiazolidinones and dispiro compounds were tested for antiproliferative activity. Seven compounds showed moderate antiproliferative activity at micromolar concentrations against cancer cell lines.

Izmest’ev A.N. , Streltsov A.A. , Kravchenko A.N. , Gazieva G.A.
5-Arylmethylidene-2-iminothiazolidin-4-ones in the synthesis of novel dispiro-fused oxindolepyrrolidineiminothiazolidinones
Chemistry of Heterocyclic Compounds. 2023. V.59. N4-5. P.309-316. DOI: 10.1007/s10593-023-03198-8 WOS Scopus OpenAlex

≡ Web of science:	WOS:001019068600003
≡ Scopus:	2-s2.0-85162195648
≡ OpenAlex:	W4381663354