Synthesis of sulfated dendrimers and studies of their anticoagulant and antiinflammatory activity

Synthesis of sulfated dendrimers and studies of their anticoagulant and antiinflammatory activity Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2011, Volume: 60, Number: 12, Pages: 2572-2578 Pages count : 7 DOI: 10.1007/s11172-011-0395-1

Authors

Krylov V.B. ¹ , Ustyuzhanina N.E. ¹ , Grachev A.A. ¹ , Ushakova N.A. ² , Preobrazhenskaya M.E. ² , Shchipunov Yu.A. ^3,4 , Wang J. ⁴ , Kim M.H. ⁴ , Kim I. ⁴ , Nifantieva N.E. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	V. N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, 10 Pogodinskaya ul., 119121, Moscow, Russian Federation
3	Institute of Chemistry, Far East Branch of the Russian Academy of Sciences, 159 prosp. 100-letiya Vladivostoka, 690022, Vladivostok, Russian Federation
4	The WCU Center for Synthetic Polymer Bioconjugate Hybrid Materials Department of Polymer Science and Engineering, Pusan National University, 609-735, Pusan, Republic of Korea

Three hyperbranched dendrimers (polyglycidols) and the corresponding sulfated derivatives, differing in the average molecular weight, were synthesized. The compounds obtained were characterized in detail by mass spectrometry and 1H and 13C NMR spectroscopy, enabling estimation of the sizes of the corresponding molecules. Assignment of signals and identification of key structural blocks were performed using 2D homo- and heteronuclear spectroscopy (COSY, HSQC). The spectra of the sulfated derivatives showed the absence of the signals for the glycerol moiety with the free OH groups, that confirms exhaustive sulfation. The studies of antiinflammatory and anticoagulant activities of the polyanionic samples showed that all the compounds manifest weak antiinflammatory activity, however, their anticoagulant activity displayed in preliminary trials seems to be considerable. The results obtained indicate that it is reasonable to study in more detail biological activity of sulfated dendrimers of this type in terms of their anticoagulant properties.

Krylov V.B. , Ustyuzhanina N.E. , Grachev A.A. , Ushakova N.A. , Preobrazhenskaya M.E. , Shchipunov Y.A. , Wang J. , Kim M.H. , Kim I. , Nifantieva N.E.
Synthesis of sulfated dendrimers and studies of their anticoagulant and antiinflammatory activity
Russian Chemical Bulletin. 2011. V.60. N12. P.2572-2578. DOI: 10.1007/s11172-011-0395-1 WOS Scopus OpenAlex

≡ Web of science:	WOS:000309129500018
≡ Scopus:	2-s2.0-84868358101
≡ OpenAlex:	W1977225978