Cascade Assembling of Isatins and Barbituric Acids: Facile and Efficient Way to 2′′H‐Dispiro[indole‐3,5′‐furo[2,3‐d]pyrimidine‐6′,5′′‐pyrimidine]‐2,2′,2′′,4′,4′′,6′′‐(1H,1′H,1′′H,3′H,3′′H)‐hexone Scaffold Научная публикация
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Journal of Heterocyclic Chemistry
ISSN: 0022-152X , E-ISSN: 1943-5193 |
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| Вых. Данные | Год: 2013, Том: 50, Номер: 5, Страницы: 1236-1241 Страниц : 6 DOI: 10.1002/jhet.1699 | ||
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Реферат:
“One-pot” transformation of isatins and barbituric acids by the direct action of the only bromine in ethanol results in the formation of substituted 2′′H-dispiro[indole-3,5′-furo[2,3-d]pyrimidine-6′,5′′-pyrimidine]-2,2′,2′′,4′,4′′,6′′-(1H,1′H,1′′H,3′H,3′′H)-hexones in 70–87% yields via complex cascade process. Dispirobarbiturates containing spiro indole and furo[2,3-d]pyrimidine framework are a class of compounds with prominent pharmacological and physiological activity. Thus, seven previously inaccessible 2′′H-dispiro[indole-3,5′-furo[2,3-d]pyrimidine-6′,5′′-pyrimidine]-2,2′,2′′,4′,4′′,6′′-(1H,1′H,1′′H,3′H,3′′H)-hexones have been synthesized that represent the new class of dispirobarbiturates.
Библиографическая ссылка:
Elinson M.N.
, Merkulova V.M.
, Ilovaisky A.I.
, Nikishin G.I.
Cascade Assembling of Isatins and Barbituric Acids: Facile and Efficient Way to 2′′H‐Dispiro[indole‐3,5′‐furo[2,3‐d]pyrimidine‐6′,5′′‐pyrimidine]‐2,2′,2′′,4′,4′′,6′′‐(1H,1′H,1′′H,3′H,3′′H)‐hexone Scaffold
Journal of Heterocyclic Chemistry. 2013. V.50. N5. P.1236-1241. DOI: 10.1002/jhet.1699 WOS Scopus OpenAlex
Cascade Assembling of Isatins and Barbituric Acids: Facile and Efficient Way to 2′′H‐Dispiro[indole‐3,5′‐furo[2,3‐d]pyrimidine‐6′,5′′‐pyrimidine]‐2,2′,2′′,4′,4′′,6′′‐(1H,1′H,1′′H,3′H,3′′H)‐hexone Scaffold
Journal of Heterocyclic Chemistry. 2013. V.50. N5. P.1236-1241. DOI: 10.1002/jhet.1699 WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000325939000038 |
| Scopus: | 2-s2.0-84884903415 |
| OpenAlex: | W2950144912 |