Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis Научная публикация
| Журнал |
Cancers
ISSN: 2072-6694 |
||
|---|---|---|---|
| Вых. Данные | Год: 2023, Том: 15, Номер: 3, Номер статьи : 756, Страниц : DOI: 10.3390/cancers15030756 | ||
| Авторы |
|
||
| Организации |
|
Реферат:
The present research paper details the synthesis of novel ionic compounds based on triterpene acids (betulinic, oleanolic and ursolic), with these acids acting both as anions and connected through a spacer with various nitrogen-containing compounds (pyridine, piperidine, morpholine, pyrrolidine, triethylamine and dimethylethanolamine) and acting as a cation. Based on the latter, a large number of ionic compounds with various counterions (BF4-, SbF6-, PF6-, CH3COO-, C6H5SO3-, m-C6H4(OH)COO- and CH3CH(OH)COO-) have been synthesized. We studied the cytotoxicity of the synthesized compounds on the example of various tumor (Jurkat, K562, U937, HL60, A2780) and conditionally normal (HEK293) cell lines. IC50 was determined, and the influence of the structure and nature of the anion and cation on the antitumor activity was specified. Intracellular signaling, apoptosis induction and effects of the most active ionic compounds on the cell cycle and mitochondria have been discussed by applying modern methods of multiparametric enzyme immunoassay and flow cytometry.
Библиографическая ссылка:
Dzhemileva L.U.
, Tuktarova R.A.
, Dzhemilev U.M.
, D’yakonov V.A.
Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis
Cancers. 2023. V.15. N3. 756 . DOI: 10.3390/cancers15030756 WOS Scopus OpenAlex
Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis
Cancers. 2023. V.15. N3. 756 . DOI: 10.3390/cancers15030756 WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000929320700001 |
| Scopus: | 2-s2.0-85147817279 |
| OpenAlex: | W4318203884 |