Three-component condensation of 2-aminothiophene-3-carboxylic acid derivatives with aldehydes and Meldrum’s acid

Three-component condensation of 2-aminothiophene-3-carboxylic acid derivatives with aldehydes and Meldrum’s acid Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2008, Volume: 57, Number: 10, Pages: 2175-2179 Pages count : 5 DOI: 10.1007/s11172-008-0295-1

Authors

Lichitsky B.V. ¹ , Komogortsev A.N. ¹ , Dudinov A.A. ¹ , Krayushkin M.M. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

New approach to the synthesis of 4,7-dihydro-5H-thieno[2,3-b]pyridin-6-ones using 2-aminothiophenes unsubstituted at position 3 of the thiophene ring has been developed. Labile 2-aminothiophenes have been obtained by the in situ decarboxylation of unstable 2-amino-3-thiophenecarboxylic acids. The three-component condensation of 2-aminothiophenes with aromatic aldehydes and the Meldrum’s acid is the key step of the process.

Lichitsky B.V. , Komogortsev A.N. , Dudinov A.A. , Krayushkin M.M.
Three-component condensation of 2-aminothiophene-3-carboxylic acid derivatives with aldehydes and Meldrum’s acid
Russian Chemical Bulletin. 2008. V.57. N10. P.2175-2179. DOI: 10.1007/s11172-008-0295-1 WOS Scopus OpenAlex

Web of science:	WOS:000270586500019
Scopus:	2-s2.0-76449095481
OpenAlex:	W1970319761

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