Rational design and synthesis of novel Syk-kinase inhibitors

Rational design and synthesis of novel Syk-kinase inhibitors Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2012, Volume: 22, Number: 2, Pages: 73-74 Pages count : 2 DOI: 10.1016/j.mencom.2012.03.006

Authors

Zeifman Alexey A. ¹ , Titov Ilya Yu. ^1,2 , Svitanko Igor V. ² , Rakitina Tatiana V. ^3,4 , Lipkin Aleksey V. ^5,4 , Stroylov Viktor S. ^1,2 , Stroganov Oleg V. ^1,2 , Novikov Fedor N. ¹ , Chilov Ghermes G. ^1,2

Affiliations

1	MolTech Ltd., 119992 Moscow, Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
3	M. M. Shemyakin–Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russian Federation
4	Russian Research Center ‘Kurchatov Institute’, 123182 Moscow, Russian Federation
5	A. N. Bach Institute of Biochemistry, Russian Academy of Sciences, 119071 Moscow, Russian Federation

Molecular modeling and subsequent synthesis of novel Syk-kinase inhibitors, 7H-pyrrolo[2,3-d]pyrimidine and 1,3,5-triazine derivatives, have been carried out. The best of the obtained compounds demonstrated to inhibit Syk-kinase activity at IC50 = 230±10 nM

Zeifman A.A. , Titov I.Y. , Svitanko I.V. , Rakitina T.V. , Lipkin A.V. , Stroylov V.S. , Stroganov O.V. , Novikov F.N. , Chilov G.G.
Rational design and synthesis of novel Syk-kinase inhibitors
Mendeleev Communications. 2012. V.22. N2. P.73-74. DOI: 10.1016/j.mencom.2012.03.006 WOS Scopus OpenAlex

Web of science:	WOS:000303692100006
Scopus:	2-s2.0-84859577522
OpenAlex:	W2034627999

DB	Citing
OpenAlex	10
Scopus	11
Web of science	10