Three-component condensation of 5-aminoimidazole derivatives with aldehydes and Meldrum’s acid. Synthesis of 3,4,6,7-tetrahydroimidazo[4,5-b]pyridin-5-ones

Three-component condensation of 5-aminoimidazole derivatives with aldehydes and Meldrum’s acid. Synthesis of 3,4,6,7-tetrahydroimidazo[4,5-b]pyridin-5-ones Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2012, Volume: 61, Number: 8, Pages: 1591-1595 Pages count : 5 DOI: 10.1007/s11172-012-0211-6

Authors

Lichitsky B.V. ¹ , Komogortsev A.N. ¹ , Dudinov A.A. ¹ , Krayushkin M.M. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

A convenient method for the synthesis of the earlier unknown substituted 3,4,6,7-tetrahydroimidazo[4,5-b]pyridin-5-ones was developed based on a three-component condensation of 5-aminoimidazole derivatives, aldehydes, and Meldrum’s acid. Unstable aminoimidazole derivatives were readily formed in situ by decarboxylation of 5-amino-4-imidazolecarboxylic acids in acidic medium at room temperature, whose sodium salts were obtained by the alkaline hydrolysis of the corresponding, readily available esters.

Lichitsky B.V. , Komogortsev A.N. , Dudinov A.A. , Krayushkin M.M.
Three-component condensation of 5-aminoimidazole derivatives with aldehydes and Meldrum’s acid. Synthesis of 3,4,6,7-tetrahydroimidazo[4,5-b]pyridin-5-ones
Russian Chemical Bulletin. 2012. V.61. N8. P.1591-1595. DOI: 10.1007/s11172-012-0211-6 WOS Scopus OpenAlex

Web of science:	WOS:000321772100014
Scopus:	2-s2.0-84887365131
OpenAlex:	W2092201213

DB	Citing
OpenAlex	8
Scopus	8
Web of science	8