New functionalized aminofurazans as potential antimitotic agents in the sea urchin embryo assay

New functionalized aminofurazans as potential antimitotic agents in the sea urchin embryo assay Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2010, Volume: 20, Number: 3, Pages: 132-134 Pages count : 3 DOI: 10.1016/j.mencom.2010.05.002

Authors

Sheremetev Aleksei B. ¹ , Dmitriev Dmitrii E. ¹ , Lagutina Nataliya K. ¹ , Raihstat Mikhail M. ¹ , Kiselyov Alex S. ² , Semenova Marina N. ³ , Ikizalp Natalie N. ⁴ , Semenov Victor V. ^1,4

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian
2	deCODE Chemistry, Chicago, IL 60517, USA
3	N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russian Federation
4	Chemical Block Ltd., 3723, Limassol, Cyprus

A series of new furazan (1,2,5-oxadiazole) derivatives based on structural overlap with combretastatin have been synthesized. Targeted molecules were evaluated using the sea urchin embryo assay; several agents demonstrated 1–4 μmol dm–3 antiproliferative activity in this in vivo model.

Sheremetev A.B. , Dmitriev D.E. , Lagutina N.K. , Raihstat M.M. , Kiselyov A.S. , Semenova M.N. , Ikizalp N.N. , Semenov V.V.
New functionalized aminofurazans as potential antimitotic agents in the sea urchin embryo assay
Mendeleev Communications. 2010. V.20. N3. P.132-134. DOI: 10.1016/j.mencom.2010.05.002 WOS Scopus OpenAlex

Web of science:	WOS:000279524500002
Scopus:	2-s2.0-77954196119
OpenAlex:	W2044011543

DB	Citing
OpenAlex	14
Scopus	12
Web of science	12