Polyalkoxybenzenes from plant raw materials 4. Parsley and dill seed extracts in the synthesis of polyalkoxy-3,5-diaryl-1,2,4-oxadiazoles with antiproliferative activity

Polyalkoxybenzenes from plant raw materials 4. Parsley and dill seed extracts in the synthesis of polyalkoxy-3,5-diaryl-1,2,4-oxadiazoles with antiproliferative activity Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2010, Volume: 59, Number: 12, Pages: 2268-2275 Pages count : 8 DOI: 10.1007/s11172-010-0387-6

Authors

Konyushkin L.D. ¹ , Godovikova T.I. ¹ , Vorontsova S.K. ¹ , Tsyganov D.V. ² , Karmanova I.B. ¹ , Raihstat M.M. ¹ , Firgang S.I. ¹ , Pokrovskii M.A. ² , Pokrovskii A.G. ² , Semenova M.N. ³ , Semenov V.V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	Novosibirsk State University, 2 ul. Pirogova, 119334, Novosibirsk, Russian Federation
3	N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, 26 ul. Vavilova, 119334, Moscow, Russian Federation

Polyalkoxy-5-(4-hydroxyphenyl)-3-phenyl-1,2,4-oxadiazoles were prepared from allylpolyalkoxybenzenes, the main metabolites of parsley and dill seeds. Due to the spatial arrangement of the aryl substituents provided by 1,2,4-oxadiozole fragment, these compounds can be considered as structural analogs of natural antimitotic combretastatins. The antimitotic activity of the synthesized compounds was evaluated in vivo using sea urchin embryo test.

Konyushkin L.D. , Godovikova T.I. , Vorontsova S.K. , Tsyganov D.V. , Karmanova I.B. , Raihstat M.M. , Firgang S.I. , Pokrovskii M.A. , Pokrovskii A.G. , Semenova M.N. , Semenov V.V.
Polyalkoxybenzenes from plant raw materials 4. Parsley and dill seed extracts in the synthesis of polyalkoxy-3,5-diaryl-1,2,4-oxadiazoles with antiproliferative activity
Russian Chemical Bulletin. 2010. V.59. N12. P.2268-2275. DOI: 10.1007/s11172-010-0387-6 WOS Scopus OpenAlex

Web of science:	WOS:000292211600011
Scopus:	2-s2.0-79958049478
OpenAlex:	W1976887437

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OpenAlex	9
Scopus	9
Web of science	10