4,5-Dihydroxyimidazolidin-2-ones in α-ureidoalkylation of N-carboxyalkyl-, N-hydroxyalkyl-, and N-(aminoalkyl)ureas 4.* α-Ureidoalkylation of N-(2-acetylaminoethyl)ureas

4,5-Dihydroxyimidazolidin-2-ones in α-ureidoalkylation of N-carboxyalkyl-, N-hydroxyalkyl-, and N-(aminoalkyl)ureas 4.* α-Ureidoalkylation of N-(2-acetylaminoethyl)ureas Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Вых. Данные

Год: 2010, Том: 59, Номер: 3, Страницы: 642-646 Страниц : 5 DOI: 10.1007/s11172-010-0117-0

Авторы

Gazieva G.A. ¹ , Lozhkin P.V. ¹ , Baranov V.V. ¹ , Kravchenko A.N. ¹ , Makhova N.N. ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

α-Ureidoalkylation of N-(2-acetylammoethyl)ureas with various 4,5-dihydroxyimidazoli-din-2-ones was systematically studied. Novel N-(2-acetylaminoethyl)glycolurils were obtained. Their yields were found to decrease both when moving from l,3-H2-to l,3-Alk2-4,5-dihydroxy-imidazolidin-2-ones and when increasing the size of the substituent at the second N atom in the starting acetylaminoethylurea. The higher yields were achieved with 4,5-diphenyl-4,5-dihydroxyimidazolidin-2-one as the starting compound. 2-(2-Acetylaminoethyl)-4-methylgly-coluril exhibits nootropic activity.

Gazieva G.A. , Lozhkin P.V. , Baranov V.V. , Kravchenko A.N. , Makhova N.N.
4,5-Dihydroxyimidazolidin-2-ones in α-ureidoalkylation of N-carboxyalkyl-, N-hydroxyalkyl-, and N-(aminoalkyl)ureas 4.* α-Ureidoalkylation of N-(2-acetylaminoethyl)ureas
Russian Chemical Bulletin. 2010. V.59. N3. P.642-646. DOI: 10.1007/s11172-010-0117-0 WOS OpenAlex

≡ Web of science:	WOS:000283994200026
≡ OpenAlex:	W2164399788