Neopetroside-B alleviates doxorubicin-induced cardiotoxicity via mitochondrial protection

Neopetroside-B alleviates doxorubicin-induced cardiotoxicity via mitochondrial protection Full article

Journal

Biomedicine & Pharmacotherapy
ISSN: 0753-3322 , E-ISSN: 1950-6007

Output data

Year: 2023, Volume: 165, Article number : 115232, Pages count : DOI: 10.1016/j.biopha.2023.115232

Authors

Yoon Chang Shin ¹ , Nifantiev Nikolay E. ² , Yashunsky Dmitry V. ² , Kim Hyoung Kyu ¹ , Han Jin ¹

Affiliations

1	Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutics Center, Department of Physiology, College of Medicine, Inje University, Busan 47397, the Republic of Korea
2	Laboratory of Glycoconjugate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia

Doxorubicin, a member of the anthracycline family, is a widely prescribed anticancer chemotherapy drug. Unfortunately, cumulative doses of doxorubicin can cause mitochondrial dysfunction, leading to acute or chronic cardiotoxicity. This study demonstrated that Neopetroside-B (NPS-B) protects cardiomyocytes in the presence of doxorubicin. NPS-B improved mitochondrial function in cardiomyocytes by increasing ATP production and oxygen consumption rates. On the other hand, NPS-B negatively influenced cancer cell lines by increasing reactive oxygen species. We analyzed NPS-B-influenced metabolites (VIP > 1.0; AUC>0.7; p < 0.05) and proteins (FC > 2.0) and constructed metabolite-protein enrichment, which showed that NPS-B affected uracil metabolism and NAD-binding proteins (e.g., aldehyde dehydrogenase and glutathione reductase) in cardiomyocytes. However, for the cancer cells, NPS-B decreased the NAD+/NADH balance, impairing cell viability. In a xenograft mouse model treated with doxorubicin, NPS-B reduced cardiac fibrosis and improved cardiac function. NPS-B may be a beneficial intervention to reducing doxorubicin-induced cardiotoxicity with anticancer effects.

Yoon C.S. , Nifantiev N.E. , Yashunsky D.V. , Kim H.K. , Han J.
Neopetroside-B alleviates doxorubicin-induced cardiotoxicity via mitochondrial protection
Biomedicine & Pharmacotherapy. 2023. V.165. 115232 . DOI: 10.1016/j.biopha.2023.115232 WOS Scopus OpenAlex

≡ Web of science:	WOS:001047240200001
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