Study of sulfated derivatives of polyhydroxy compounds as inhibitors of blood coagulation

Study of sulfated derivatives of polyhydroxy compounds as inhibitors of blood coagulation Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2010, Volume: 59, Number: 1, Pages: 232-235 Pages count : 4 DOI: 10.1007/s11172-010-0067-6

Authors

Krylov V.B. ¹ , Ushakova N.A. ² , Ustyuzhanina N.E. ¹ , Preobrazhenskaya M.E. ² , Yashunsky D.V. ² , Menshov V.M. ¹ , Tsvetkov D.E. ¹ , Sharma G.V.M. ³ , Radha Krishna P. ³ , Nifantiev N.E. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2	V. N. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, 10 ul. Pogodinskaya, 119121 Moscow, Russian Federation
3	Indian Institute of Chemical Technology, Hyderabad 500 007, India

Persulfated derivatives of natural polyhydroxy compounds, such as lignans secoisolariciresinol, and isolariciresinol, flavonoid dihydroquercetin, and myo-inositol, have been synthesized. The ability of these compounds to inhibit the intrinsic pathway of blood coagulation (APTT-test) and to reduce the activity of coagulation factor Xa in the presence of antithrombin(III) has been studied.

Krylov V.B. , Ushakova N.A. , Ustyuzhanina N.E. , Preobrazhenskaya M.E. , Yashunsky D.V. , Menshov V.M. , Tsvetkov D.E. , Sharma G.V.M. , Radha Krishna P. , Nifantiev N.E.
Study of sulfated derivatives of polyhydroxy compounds as inhibitors of blood coagulation
Russian Chemical Bulletin. 2010. V.59. N1. P.232-235. DOI: 10.1007/s11172-010-0067-6 WOS Scopus OpenAlex

≡ Web of science:	WOS:000277959600027
≡ Scopus:	2-s2.0-77955864462
≡ OpenAlex:	W2038534605