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Electrochemically induced multicomponent assembling of isatins, 4-hydroxyquinolin-2(1H)-one and malononitrile: a convenient and efficient way to functionalized spirocyclic [indole-3,4′-pyrano[3,2-c]quinoline] scaffold Full article

Journal Molecular Diversity
ISSN: 1573-501X , E-ISSN: 1381-1991
Output data Year: 2010, Volume: 14, Number: 4, Pages: 833-839 Pages count : 7 DOI: 10.1007/s11030-009-9207-z
Authors Elinson Michail N. 1 , Merkulova Valentina M. 1 , Ilovaisky Alexey I. 1 , Demchuk Dmitry V. 1 , Belyakov Pavel A. 1 , Nikishin Gennady I. 1
Affiliations
1 N. D. Zelinsky Institute of Organic Chemistry

Abstract: Electrochemically induced catalytic multicomponent transformation of isatins, 4-hydroxyquinolin-2(1H)-one and malononitrile in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of spirooxindoles with fused functionalized indole-3,4′-pyrano[3,2-c]quinoline] scaffold in 75–91% substance yields and 500-600% current yield. The developed efficient electrocatalytic approach to medicinally relevant [indole-3,4′-pyrano[3,2-c]quinoline] scaffold is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a novel example of facile environmentally benign synthetic concept for electrocatalytic multicomponent reactions.
Cite: Elinson M.N. , Merkulova V.M. , Ilovaisky A.I. , Demchuk D.V. , Belyakov P.A. , Nikishin G.I.
Electrochemically induced multicomponent assembling of isatins, 4-hydroxyquinolin-2(1H)-one and malononitrile: a convenient and efficient way to functionalized spirocyclic [indole-3,4′-pyrano[3,2-c]quinoline] scaffold
Molecular Diversity. 2010. V.14. N4. P.833-839. DOI: 10.1007/s11030-009-9207-z WOS Scopus OpenAlex
Identifiers:
Web of science: WOS:000284598600024
Scopus: 2-s2.0-78650170920
OpenAlex: W2083527014
Citing:
DB Citing
OpenAlex 49
Scopus 51
Web of science 51
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