Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors

Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2021, Volume: 31, Number: 1, Pages: 42-45 Pages count : 4 DOI: 10.1016/j.mencom.2021.01.012

Authors

Kulikov Alexander S. ¹ , Epishina Margarita A. ¹ , Zhilin Egor S. ¹ , Shuvaev Alexander D. ^2,1 , Fershtat Leonid L. ¹ , Makhova Nina N. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation

A simple and effective protocol for the synthesis of 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides includes a transformation of accessible 3,4-diacetyl-5-methyl-1H-pyrazoles into the corresponding 1,4-dioximes followed by their N2O4- mediated oxidative cyclization. All transformations proceed under mild conditions in good to high yields. According to the Griess assay, synthesized 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides showed promising NO-donor profiles producing NO in a wide range of concentrations.

Kulikov A.S. , Epishina M.A. , Zhilin E.S. , Shuvaev A.D. , Fershtat L.L. , Makhova N.N.
Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors
Mendeleev Communications. 2021. V.31. N1. P.42-45. DOI: 10.1016/j.mencom.2021.01.012 WOS Scopus OpenAlex

Web of science:	WOS:000620734500012
Scopus:	2-s2.0-85100627098
OpenAlex:	W3128034413

DB	Citing
OpenAlex	18
Scopus	15
Web of science	18