Three-component condensation of 3-aminothiophene-2-carboxylic acid derivatives with aldehydes and Meldrum’s acid

Three-component condensation of 3-aminothiophene-2-carboxylic acid derivatives with aldehydes and Meldrum’s acid Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2009, Volume: 58, Number: 2, Pages: 387-391 Pages count : 5 DOI: 10.1007/s11172-010-0020-8

Authors

Lichitsky B.V. ¹ , Belyi R.M. ¹ , Komogortsev A.N. ¹ , Dudinov A.A. ¹ , Krayushkin M.M. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

A convenient method was developed for the synthesis of the previously unknown substituted 6,7-dihydro-4H-thieno[3,2-b]pyridin-5-ones based on the three-component condensation of 3-aminothiophenes, Meldrum’s acid, and aromatic aldehydes. 3-Aminothiophenes are easily formed in situ by decarboxylation of 3-aminothiophene-2-carboxylic acids in an acidic medium. Sodium salts of the latter acids were prepared by alkaline hydrolysis of the corresponding available esters.

Lichitsky B.V. , Belyi R.M. , Komogortsev A.N. , Dudinov A.A. , Krayushkin M.M.
Three-component condensation of 3-aminothiophene-2-carboxylic acid derivatives with aldehydes and Meldrum’s acid
Russian Chemical Bulletin. 2009. V.58. N2. P.387-391. DOI: 10.1007/s11172-010-0020-8 WOS Scopus Scopus OpenAlex

Web of science:	WOS:000275907000019
Scopus:	2-s2.0-77955732821 \| 2-s2.0-77950206271
OpenAlex:	W2916597048

DB	Citing
OpenAlex	7
Scopus	8 8
Web of science	12