Synthesis and antimicrobial activity of geminal bis-hydroperoxides

Synthesis and antimicrobial activity of geminal bis-hydroperoxides Full article

Journal

Pharmaceutical Chemistry Journal
ISSN: 0091-150X , E-ISSN: 1573-9031

Output data

Year: 2010, Volume: 44, Number: 5, Pages: 248-250 Pages count : 3 DOI: 10.1007/s11094-010-0441-6

Authors

Tropina V.I. ¹ , Krivykh O.V. ² , Sadchikova N.P. ² , Terent’ev A.O. ³ , Krylov I.B. ³

Affiliations

1	All-Russia Scientific Center for Safety Testing of Biologically Active Substances, Ministry of Public Health of the Russian Federation, Staraya Kupavna, Moscow Oblast, Russia
2	Sechenov Medical Academy, Moscow, Russia
3	Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

A series of six new geminal bis-hydroperoxides were synthesized based on cyclic ketones. Experiments in vitro show that the synthesized compounds exhibit pronounced antimicrobial properties that are comparable with the effect of some antiseptics and, to a lesser extent, antibiotics. Tests on B. cereus, E. coli, P. aeruginosa, S. aureus, C. albicans, and A. niger showed that bis-hydroperoxides were similar to hydrogen peroxide with respect to both the spectrum of action and the MIC level (0.1, 1.0, and 10 mg/mL), which is evidence for a similar mechanism of antimicrobial action.

Tropina V.I. , Krivykh O.V. , Sadchikova N.P. , Terent’ev A.O. , Krylov I.B.
Synthesis and antimicrobial activity of geminal bis-hydroperoxides
Pharmaceutical Chemistry Journal. 2010. V.44. N5. P.248-250. DOI: 10.1007/s11094-010-0441-6 WOS Scopus OpenAlex

≡ Web of science:	WOS:000283370200003
≡ Scopus:	2-s2.0-78149410925
≡ OpenAlex:	W2020884350