Synthesis of 4-(trifluoromethyl)pyrido[4,3-d]pyrimidine derivatives

Synthesis of 4-(trifluoromethyl)pyrido[4,3-d]pyrimidine derivatives Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2010, Volume: 59, Number: 7, Pages: 1403-1407 Pages count : 5 DOI: 10.1007/s11172-010-0254-5

Authors

Vasil’ev L.S. ¹ , Baranin S.V. ¹ , Ignatenko A.V. ¹ , Nelyubina Yu.V. ² , Dorokhov V.A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

Earlier unknown 4-alkoxy-and 4-hydroxy-5-methyl-4-trifluoromethyl-1,4-dihydropyri-do[4,3-d]pyrimidines were obtained by the reaction of 5-acetyl-4-dimethylaminovinyl-6-(trifluoromethyl)pyrimidine with alcoholic (aqueous) solutions of NH3. The former eliminate alcohol (water) on sublimation in vacuo to be converted to 5-methyl-4-(trifluoromethyl)-pyrido[4,3-d]pyrimidine. The latter upon the action of alcohols (water) under mild conditions were reverted to the corresponding 4-alkoxy-and 4-hydroxydihydropyrido[4,3-d]pyrimidines.

Vasil’ev L.S. , Baranin S.V. , Ignatenko A.V. , Nelyubina Y.V. , Dorokhov V.A.
Synthesis of 4-(trifluoromethyl)pyrido[4,3-d]pyrimidine derivatives
Russian Chemical Bulletin. 2010. V.59. N7. P.1403-1407. DOI: 10.1007/s11172-010-0254-5 WOS Scopus OpenAlex

≡ Web of science:	WOS:000285884500017
≡ Scopus:	2-s2.0-79951712014
≡ OpenAlex:	W2059346638