Solvent-free cascade reaction: direct multicomponent assembling of 2-amino-4H-chromene scaffold from salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes Научная публикация
| Журнал |
Tetrahedron
ISSN: 0040-4020 , E-ISSN: 1464-5416 |
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| Вых. Данные | Год: 2010, Том: 66, Номер: 23, Страницы: 4043-4048 Страниц : 6 DOI: 10.1016/j.tet.2010.04.024 | ||
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Реферат:
The new type of solvent-free cascade reaction was found: the direct heating of the mixture of salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes at 60 °C in the presence of catalytic amounts of KF or NaOAc results in the formation of 2-amino-4-(1-nitroalkyl)-4H-chromene-3-carbonitriles or methyl 2-amino-4-(1-nitroalkyl)-4H-chromene-3-carboxylates in 80–90% yields. Thus, the new simple and efficient solvent-free ‘one-pot’ way to substituted medicinally privileged 2-amino-4H-chromene scaffold was found directly from such simple and reasonable starting compounds as salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes.
Библиографическая ссылка:
Elinson M.N.
, Ilovaisky A.I.
, Merkulova V.M.
, Belyakov P.A.
, Chizhov A.O.
, Nikishin G.I.
Solvent-free cascade reaction: direct multicomponent assembling of 2-amino-4H-chromene scaffold from salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes
Tetrahedron. 2010. V.66. N23. P.4043-4048. DOI: 10.1016/j.tet.2010.04.024 WOS Scopus OpenAlex
Solvent-free cascade reaction: direct multicomponent assembling of 2-amino-4H-chromene scaffold from salicylaldehyde, malononitrile or cyanoacetate and nitroalkanes
Tetrahedron. 2010. V.66. N23. P.4043-4048. DOI: 10.1016/j.tet.2010.04.024 WOS Scopus OpenAlex
Идентификаторы БД:
| Web of science: | WOS:000278198000010 |
| Scopus: | 2-s2.0-77953122591 |
| OpenAlex: | W2122682651 |