Synthesis and Evaluation on the Fungicidal Activity of S-Alkyl Substituted Thioglycolurils

Synthesis and Evaluation on the Fungicidal Activity of S-Alkyl Substituted Thioglycolurils Full article

Journal

International Journal of Molecular Sciences
ISSN: 1661-6596 , E-ISSN: 1422-0067

Output data

Year: 2023, Volume: 24, Number: 6, Article number : 5756, Pages count : DOI: 10.3390/ijms24065756

Authors

Vinogradova Ekaterina E. ¹ , Alekseenko Anna L. ² , Popkov Sergey V. ² , Kolotyrkina Natalya G. ¹ , Kravchenko Angelina N. ¹ , Gazieva Galina A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prosp., Moscow 119991, Russia
2	Faculty of Chemical-Pharmaceutical Technologies and Biomedical Preparations, Mendeleev University of Chemical Technology, 9 Miusskaya Sq., Moscow 125047, Russia

A series of S-alkyl substituted thioglycolurils was prepared through the alkylation of corresponding thioglycolurils with halogenoalkanes and tested for their fungicidal activity against six phytopathogenic fungi from different taxonomic classes: Venturia inaequalis, Rhizoctonia solani, Fusarium oxysporum, Fusarium moniliforme, Bipolaris sorokiniana, and Sclerotinia sclerotiorum, and two pathogenic yeasts: Candida albicans and Cryptococcus neoformans var. grubii. A number of S-alkyl substituted thioglycolurils exhibited high activity against Venturia inaequalis and Rhizoctonia solani (85–100% mycelium growth inhibition), and moderate activity against other phytopathogens. S-Ethyl substituted thioglycolurils possessed a high activity against Candida albicans. Additionally, the hemolytic and cytotoxic properties of promising derivatives were determined using human red blood cells and human embryonic kidney cells, respectively. Two S-ethyl derivatives possessed both low cytotoxicity against normal human cells and high fungicidal activity against Candida albicans.

Vinogradova E.E. , Alekseenko A.L. , Popkov S.V. , Kolotyrkina N.G. , Kravchenko A.N. , Gazieva G.A.
Synthesis and Evaluation on the Fungicidal Activity of S-Alkyl Substituted Thioglycolurils
International Journal of Molecular Sciences. 2023. V.24. N6. 5756 . DOI: 10.3390/ijms24065756 WOS Scopus OpenAlex

≡ Web of science:	WOS:000958315300001
≡ Scopus:	2-s2.0-85151110522
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