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4,5-Dihydroxyimidazolidin-2-ones in an α-ureidoalkylation reaction of N-(carboxyalkyl)-, N-(hydroxyalkyl)-, and N-(aminoalkyl)ureas 3. α-Ureidoalkylation of N-[2-(dimethylamino)ethyl]urea Full article

Journal Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285
Output data Year: 2009, Volume: 58, Number: 12, Pages: 2488-2493 Pages count : 6 DOI: 10.1007/s11172-009-0348-0
Authors Gazieva G.A. 1 , Lozhkin P.V. 1 , Baranov V.V. 1 , Nelyubina Yu.V. 2 , Kravchenko A.N. 1 , Makhova N.N. 1
Affiliations
1 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2 A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

Abstract: α-Ureidoalkylation of N-[2-(dimethylamino)ethyl]urea with 1,3-unsubstituted, 1,3-dialkyl-, and 1,3-dimethyl-4,5-diphenyl-4,5-dihydroxyimidazolidin-2-ones(thiones) was systematically studied. Hitherto unknown N-[2-(dimethylamino)ethyl]glycolurils and their hydrochlorides were synthesized. The yields of the target glycoluril hydrochlorides decreased on going from 1,3-H2- to 1,3-dialkyl-4,5-dihydroxyimidazolidin-2-ones and increased with the introduction of phenyl groups at the positions 4 and 5 of the starting 4,5-dihydroxyimidazolidin-2-one. X-ray diffraction study showed that 2-[2-(dimethylamino)ethyl]glycoluril crystallizes in the form of a conglomerate.
Cite: Gazieva G.A. , Lozhkin P.V. , Baranov V.V. , Nelyubina Y.V. , Kravchenko A.N. , Makhova N.N.
4,5-Dihydroxyimidazolidin-2-ones in an α-ureidoalkylation reaction of N-(carboxyalkyl)-, N-(hydroxyalkyl)-, and N-(aminoalkyl)ureas 3. α-Ureidoalkylation of N-[2-(dimethylamino)ethyl]urea
Russian Chemical Bulletin. 2009. V.58. N12. P.2488-2493. DOI: 10.1007/s11172-009-0348-0 WOS Scopus OpenAlex
Identifiers:
≡ Web of science: WOS:000283365700013
≡ Scopus: 2-s2.0-84867894587
≡ OpenAlex: W2012579842
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