Photoredox Fluoroalkylation of Hydrazones in Neutral and Reductive Modes

Photoredox Fluoroalkylation of Hydrazones in Neutral and Reductive Modes Full article

Journal

Advanced Synthesis & Catalysis
ISSN: 1615-4169 , E-ISSN: 1615-4150

Output data

Year: 2021, Volume: 363, Number: 4, Pages: 1152-1158 Pages count : 7 DOI: 10.1002/adsc.202001381

Authors

van der Worp Boris A. ^1,2 , Kosobokov Mikhail D. ² , Levin Vitalij V. ² , Dilman Alexander D. ²

Affiliations

1	Lomonosov Moscow State University Department of Chemistry 119991 Moscow Leninskie Gory 1–3 Russian Federation
2	N. D. Zelinsky Institute of Organic Chemistry, 119991 Moscow, Leninsky prosp. 47, Russian Federation

Visible light promoted fluoroalkylation of hydrazones using 4-perfluoropyridine sulfides as fluoroalkyl radical sources is described. The process can proceed in neutral and reductive modes delivering either hydrazones or hydrazines, respectively, depending on structure of starting substrates and reaction conditions. For the reductive process, ascorbic acid is used as a terminal reductant, which recycles the photocatalyst and serves as a source of hydrogen towards nitrogen-centered radicals.

van der Worp B.A. , Kosobokov M.D. , Levin V.V. , Dilman A.D.
Photoredox Fluoroalkylation of Hydrazones in Neutral and Reductive Modes
Advanced Synthesis & Catalysis. 2021. V.363. N4. P.1152-1158. DOI: 10.1002/adsc.202001381 WOS Scopus OpenAlex

≡ Web of science:	WOS:000603453800001
≡ Scopus:	2-s2.0-85098480343
≡ OpenAlex:	W3114802650