(1,2,3-Triazol-4-yl)benzenamines: Synthesis and activity against VEGF receptors 1 and 2

(1,2,3-Triazol-4-yl)benzenamines: Synthesis and activity against VEGF receptors 1 and 2 Full article

Journal

Bioorganic & Medicinal Chemistry Letters
ISSN: 1464-3405 , E-ISSN: 0960-894X

Output data

Year: 2009, Volume: 19, Number: 5, Pages: 1344-1348 Pages count : 5 DOI: 10.1016/j.bmcl.2009.01.046

Authors

Kiselyov Alexander S. ¹ , Semenova Marina ² , Semenov Victor V. ³

Affiliations

1	deCODE, 2501 Davey Road, Woodridge, IL 60517, USA
2	Institute of Developmental Biology, RAS, 26 Vavilov Str., 119334 Moscow, Russia
3	Zelinsky Institute of Organic Chemistry, RAS, 47 Leninsky Prospect, 117913 Moscow, Russia

Derivatives of (1,2,3-triazol-4-yl)benzenamines are described as potent and ATP-competitive inhibitors of vascular endothelial growth factor receptors I and II (VEGFR-1/2). A number of compounds exhibited VEGFR-2 and VEGFR-1 inhibitory activity comparable to that of Vatalanib™ in both HTRF enzymatic and cellular assays.

Kiselyov A.S. , Semenova M. , Semenov V.V.
(1,2,3-Triazol-4-yl)benzenamines: Synthesis and activity against VEGF receptors 1 and 2
Bioorganic & Medicinal Chemistry Letters. 2009. V.19. N5. P.1344-1348. DOI: 10.1016/j.bmcl.2009.01.046 WOS Scopus OpenAlex

Web of science:	WOS:000263891200015
Scopus:	2-s2.0-60449096371
OpenAlex:	W2098544651

DB	Citing
OpenAlex	21
Scopus	24
Web of science	21