2-(2-(4-Methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic Acid | Sciact

2-(2-(4-Methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic Acid Научная публикация

Журнал

Molbank
ISSN: 1422-8599

Вых. Данные

Год: 2022, Том: 2022, Номер: 1, Номер статьи : M1315, Страниц : DOI: 10.3390/m1315

Авторы

Lichitsky Boris V. ¹ , Komogortsev Andrey N. ¹ , Melekhina Valeriya G. ¹

Организации

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Science, Leninsky Pr., 47, 119991 Moscow, Russia

A simple and efficient protocol for the synthesis of the previously unknown 2-(2-(4-methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic acid was elaborated. The suggested method is based on the telescoped multicomponent reaction of 8-hydroxyquinoline, 4-methylglyoxal, and Meldrum’s acid. The studied process includes the initial interaction of the starting compounds in MeCN followed by intramolecular cyclization to the target product in refluxing acetic acid. The advantage of this approach is the application of readily available starting materials, atom economy, and a simple work-up procedure. The structure of the synthesized furylacetic acid derivative was proven by 1H, 13C, 2D-NMR, IR spectroscopy, and high-resolution mass spectrometry.

Lichitsky B.V. , Komogortsev A.N. , Melekhina V.G.
2-(2-(4-Methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic Acid
Molbank. 2022. V.2022. N1. M1315 . DOI: 10.3390/m1315 WOS Scopus OpenAlex

Web of science:	WOS:000774091600001
Scopus:	2-s2.0-85123120067
OpenAlex:	W4206698143

БД	Цитирований
OpenAlex	3
Scopus	2
Web of science	2