NoteIdentification of 5,7-diacetamido-3,5,7,9-tetradeoxy-d-glycero-l-manno-non-2-ulosonic acid (di-N-acetyl-8-epipseudaminic acid) in the capsular polysaccharide of Acinetobacter baumannii Res546

NoteIdentification of 5,7-diacetamido-3,5,7,9-tetradeoxy-d-glycero-l-manno-non-2-ulosonic acid (di-N-acetyl-8-epipseudaminic acid) in the capsular polysaccharide of Acinetobacter baumannii Res546 Full article

Journal

Carbohydrate Research
ISSN: 1873-426X , E-ISSN: 0008-6215

Output data

Year: 2022, Volume: 513, Article number : 108531, Pages count : DOI: 10.1016/j.carres.2022.108531

Authors

Shashkov Alexander S. ¹ , Arbatsky Nikolay P. ¹ , Senchenkova Sof'ya N. ¹ , Perepelov Andrei V. ¹ , Chizhov Alexander O. ¹ , Dmitrenok Andrei S. ¹ , Shneider Mikhail M. ² , Knirel Yuriy A. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2	M.M. Shemyakin & Y.A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

A structurally diverse capsular polysaccharide that surrounds the bacterial cell plays an important role in virulence of Acinetobacter baumannii, a cause of nosocomial infections worldwide. Various isomers of 5,7-diacylamido-3,5,7,9-tetradeoxynon-2-ulosonic acid have been identified as components of bacterial polysaccharides. In this work, we report on the identification of a new isomer having the d-glycero-l-manno configuration (8-epipseudaminic acid) in the capsular polysaccharide of A. baumannii Res546. The higher sugar was isolated by Smith degradation of the polysaccharide followed by mild acid hydrolysis and identified by a comparison with all isomers using NMR spectroscopy and optical rotation.

Shashkov A.S. , Arbatsky N.P. , Senchenkova S.N. , Perepelov A.V. , Chizhov A.O. , Dmitrenok A.S. , Shneider M.M. , Knirel Y.A.
NoteIdentification of 5,7-diacetamido-3,5,7,9-tetradeoxy-d-glycero-l-manno-non-2-ulosonic acid (di-N-acetyl-8-epipseudaminic acid) in the capsular polysaccharide of Acinetobacter baumannii Res546
Carbohydrate Research. 2022. V.513. 108531 . DOI: 10.1016/j.carres.2022.108531 WOS Scopus OpenAlex

Web of science:	WOS:000834850400006
Scopus:	2-s2.0-85125453649
OpenAlex:	W4214595980

DB	Citing
OpenAlex	8
Scopus	6
Web of science	6