A comparative evaluation of monomethoxy substituted o-diarylazoles as antiproliferative microtubule destabilizing agents

A comparative evaluation of monomethoxy substituted o-diarylazoles as antiproliferative microtubule destabilizing agents Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2022, Volume: 32, Number: 1, Pages: 120-122 Pages count : 3 DOI: 10.1016/j.mencom.2022.01.039

Authors

Silyanova Eugenia A. ¹ , Ushkarov Vladimir I. ¹ , Samet Alexander V. ¹ , Maksimenko Anna S. ¹ , Koblov Ivan A. ^2,1 , Kislyi Victor P. ¹ , Semenova Marina N. ³ , Semenov Victor V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
2	D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation
3	N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russian Federation

Monomethoxy substituted o-diarylazoles with isoxazole, triazole, pyrazole, or pyrrole linkers were synthesized and evaluated for antimitotic antitubulin activity in a sea urchin embryo model. Structure–activity relationship study revealed that only isoxazole heterocycle together with the unsubstituted phenyl ring next to the heteroatom endowed the molecule with appropriate configuration to exhibit antiproliferative effect by microtubule destabilizing mode of action.

Silyanova E.A. , Ushkarov V.I. , Samet A.V. , Maksimenko A.S. , Koblov I.A. , Kislyi V.P. , Semenova M.N. , Semenov V.V.
A comparative evaluation of monomethoxy substituted o-diarylazoles as antiproliferative microtubule destabilizing agents
Mendeleev Communications. 2022. V.32. N1. P.120-122. DOI: 10.1016/j.mencom.2022.01.039 WOS Scopus OpenAlex

Web of science:	WOS:000766626200039
Scopus:	2-s2.0-85125581966
OpenAlex:	W4214821995

DB	Citing
OpenAlex	11
Scopus	12
Web of science	11