Synthesis of 2-[2-(Ethoxymethoxy)phenyl]spiro[cyclopropane-1,2′-indene]-1′,3′-dione

Synthesis of 2-[2-(Ethoxymethoxy)phenyl]spiro[cyclopropane-1,2′-indene]-1′,3′-dione Full article

Journal

Molbank
ISSN: 1422-8599

Output data

Year: 2023, Volume: 2023, Number: 1, Article number : M1604, Pages count : DOI: 10.3390/m1604

Authors

Ivanova Olga A. ¹ , Shorokhov Vitaly V. ¹ , Andreev Ivan A. ^2,3 , Ratmanova Nina K. ^2,3 , Rybakov Victor B. ¹ , Strel’tsova Elena D. ³ , Trushkov Igor V. ³

Affiliations

1	Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russia
2	Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Samory Mashela St. 1, Moscow 117997, Russia
3	N.D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, Leninsky Pr. 47, Moscow 119991, Russia

An 1,3-indanedione-derived donor–acceptor cyclopropane, bearing the ethoxymethyl-protected phenolic group at the ortho-position of the donor aryl substituent, has been synthesized using a reaction sequence involving the Knoevenagel condensation of 1,3-indanedione with the corresponding protected salicylaldehyde followed by the Corey–Chaykovsky cyclopropanation of the obtained adduct with dimethylsulfoxonium methylide. The structure of the synthesized cyclopropane was unambiguously proved by single-crystal X-ray diffraction data.

Ivanova O.A. , Shorokhov V.V. , Andreev I.A. , Ratmanova N.K. , Rybakov V.B. , Strel’tsova E.D. , Trushkov I.V.
Synthesis of 2-[2-(Ethoxymethoxy)phenyl]spiro[cyclopropane-1,2′-indene]-1′,3′-dione
Molbank. 2023. V.2023. N1. M1604 . DOI: 10.3390/m1604 WOS Scopus OpenAlex

Web of science:	WOS:000959948000001
Scopus:	2-s2.0-85152251682
OpenAlex:	W4324143090

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