2,4-Diamino-5-(5-hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile

2,4-Diamino-5-(5-hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile Научная публикация

Журнал

Molbank
ISSN: 1422-8599

Вых. Данные

Год: 2023, Том: 2023, Номер: 1, Номер статьи : M1541, Страниц : DOI: 10.3390/m1541

Авторы

Ryzhkova Yuliya E. ¹ , Ryzhkov Fedor V. ¹ , Maslov Oleg I. ¹ , Elinson Michail N. ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, Russia

5H-Chromeno[2,3-b]pyridines are important compounds with industrial, biological, and medicinal properties. In this short note, the multicomponent reaction of salicylaldehyde, malononitrile dimer, and 2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one in dimethyl sulfoxide at ambient temperature was investigated to give 2,4-diamino-5-(5-hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile with good yield. The structure of the previously unknown chromeno[2,3-b]pyridine derivative was confirmed by elemental analysis, mass, nuclear magnetic resonance, and infrared spectroscopy data. The ADME (absorption, distribution, metabolism, and excretion) properties were also assessed.

Ryzhkova Y.E. , Ryzhkov F.V. , Maslov O.I. , Elinson M.N.
2,4-Diamino-5-(5-hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5H-chromeno[2,3-b]pyridine-3-carbonitrile
Molbank. 2023. V.2023. N1. M1541 . DOI: 10.3390/m1541 WOS Scopus OpenAlex

≡ Web of science:	WOS:000958609200001
≡ Scopus:	2-s2.0-85151090433
≡ OpenAlex:	W4317243021