6,7-Dihydroxy-5,8-dimethoxy-2H-chromen-2-one

6,7-Dihydroxy-5,8-dimethoxy-2H-chromen-2-one Full article

Journal

Molbank
ISSN: 1422-8599

Output data

Year: 2023, Volume: 2023, Number: 3, Article number : M1702, Pages count : DOI: 10.3390/m1702

Authors

Adaeva Olga I. ¹ , Demchuk Dmitry V. ¹ , Semenov Victor V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russia

This article presents a novel approach for synthesizing a new 5,8-dimethoxy derivative of esculetin via the selective cleavage of the methylene bridge in sabandin—naturally occurring and easily synthetically accessible methoxylated coumarin. A high selectivity is achieved by using acetoxylation of methylenedioxy group with lead tetraacetate. Natural coumarin sabandin as a starting compound was prepared in a few simple steps from 5-allyl-4,7-dimethoxybenzo[d][1,3]dioxole (apiol), which is readily available from parsley and dill seed extracts. The developed method enables an efficient and straightforward synthesis of a new derivative of esculetin with potential medicinal and therapeutic applications.

Adaeva O.I. , Demchuk D.V. , Semenov V.V.
6,7-Dihydroxy-5,8-dimethoxy-2H-chromen-2-one
Molbank. 2023. V.2023. N3. M1702 . DOI: 10.3390/m1702 WOS Scopus OpenAlex

Web of science:	WOS:001076610000001
Scopus:	2-s2.0-85172806561
OpenAlex:	W4385223840

DB	Citing
OpenAlex	7
Scopus	3
Web of science	4