Cross reacting material (CRM197) as a carrier protein for carbohydrate conjugate vaccines targeted at bacterial and fungal pathogens

Cross reacting material (CRM197) as a carrier protein for carbohydrate conjugate vaccines targeted at bacterial and fungal pathogens Review

Journal

International Journal of Biological Macromolecules
ISSN: 1879-0003 , E-ISSN: 0141-8130

Output data

Year: 2022, Volume: 218, Pages: 775-798 Pages count : 24 DOI: 10.1016/j.ijbiomac.2022.07.137

Authors

Khatuntseva E.A. ¹ , Nifantiev N.E. ¹

Affiliations

1	Laboratory of Glycoconjugate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia

This paper gives an overview of conjugate glycovaccines which contain recombinant diphtheria toxoid CRM197 as a carrier protein. A special focus is given to synthetic methods used for preparation of neoglycoconjugates of CRM197 with oligosaccharide epitopes of cell surface carbohydrates of pathogenic bacteria and fungi. Syntheses of commercial vaccines and laboratory specimen on the basis of CRM197 are outlined briefly.

Khatuntseva E.A. , Nifantiev N.E.
Cross reacting material (CRM197) as a carrier protein for carbohydrate conjugate vaccines targeted at bacterial and fungal pathogens
International Journal of Biological Macromolecules. 2022. V.218. P.775-798. DOI: 10.1016/j.ijbiomac.2022.07.137 WOS Scopus OpenAlex

≡ Web of science:	WOS:000895330400007
≡ Scopus:	2-s2.0-85135074328
≡ OpenAlex:	W4286436695