The synthesis and antitumor activity of novel 1-alkyl-3-phenyland 3-alkyl-1-phenylimidazothiazolotriazines

The synthesis and antitumor activity of novel 1-alkyl-3-phenyland 3-alkyl-1-phenylimidazothiazolotriazines Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2024, Volume: 60, Pages: 196-204 Pages count : 9 DOI: 10.1007/s10593-024-03318-y

Authors

Izmest’ev Alexei N. ¹ , Isakov Sergey S. ¹ , Kravchenko Angelina N. ¹ , Gazieva Galina A. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave, Moscow, 119991, Russia

Two groups of isomeric imidazothiazolo[1,2,4]triazines and their oxindolylidene derivatives were obtained from 1-alkyl-3-aryl-4,5-dihydroxyimidazolidin-2-(thi)ones. One of the synthesized imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazine derivatives showed high cytostatic activity at a concentration of 10 μmol/l against four lines of tumor cells: HL-60(TB) (leukemia, –16.1% growth rate), SF-539 (CNS cancer, –2.6% growth rate), MDA-MB-435 (melanoma, –21.2% growth rate), and RXF 393 (kidney cancer, –6.1 % growth rate).

Izmest’ev A.N. , Isakov S.S. , Kravchenko A.N. , Gazieva G.A.
The synthesis and antitumor activity of novel 1-alkyl-3-phenyland 3-alkyl-1-phenylimidazothiazolotriazines
Chemistry of Heterocyclic Compounds. 2024. V.60. P.196-204. DOI: 10.1007/s10593-024-03318-y WOS Scopus OpenAlex

≡ Web of science:	WOS:001238563700001
≡ Scopus:	2-s2.0-85195197700
≡ OpenAlex:	W4399356145