Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model

Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model Full article

Journal

mSphere
ISSN: 2379-5042

Output data

Year: 2020, Volume: 5, Number: 1, Article number : e00688-19, Pages count : DOI: 10.1128/msphere.00688-19

Authors

Wong Sarah Sze Wah ¹ , Krylov Vadim B. ² , Argunov Dmitry A. ² , Karelin Alexander A. ² , Bouchara Jean-Phillipe ³ , Fontaine Thierry ¹ , Latgé Jean-Paul ¹ , Nifantiev Nikolay E. ²

Affiliations

1	Unité des Aspergillus, Institut Pasteur Paris France
2	Laboratory of Glycoconjugate Chemistry N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences Moscow Russia
3	Groupe d’Etude des Interactions Hôte-Pathogène (EA 3142), UNIV Brest, Angers, France

Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.

Wong S.S.W. , Krylov V.B. , Argunov D.A. , Karelin A.A. , Bouchara J-P. , Fontaine T. , Latgé J-P. , Nifantiev N.E.
Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model
mSphere. 2020. V.5. N1. e00688-19 . DOI: 10.1128/msphere.00688-19 WOS OpenAlex

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