Unexpected stereoselective sodium acetate catalyzed multicomponent cyclization of aryl aldehydes, malononitrile and acetone into cis-4-dicyanomethylene-2,6-diarylcyclohexane-1,1-dicarbonitriles

Unexpected stereoselective sodium acetate catalyzed multicomponent cyclization of aryl aldehydes, malononitrile and acetone into cis-4-dicyanomethylene-2,6-diarylcyclohexane-1,1-dicarbonitriles Full article

Journal

Tetrahedron Letters
ISSN: 0040-4039 , E-ISSN: 1873-3581

Output data

Year: 2007, Volume: 48, Number: 38, Pages: 6614-6619 Pages count : 6 DOI: 10.1016/j.tetlet.2007.07.119

Authors

Elinson Michail N. ¹ , Vereshchagin Anatolii N. ¹ , Feducovich Sergey K. ¹ , Zaimovskaya Tatyana A. ² , Starikova Zoya A. ³ , Belyakov Pavel A. ¹ , Nikishin Gennady I. ¹

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Leninsky prospect 47, 119991 Moscow, Russia
2	A.V. Topchiev Institute of Petrochemical Synthesis, Leninsky prospect 29, 119991 Moscow, Russia
3	A.N. Nesmeyanov Institute of Organoelement compounds, ul. Vavilova 28, 119991 Moscow, Russia

A new type of multicomponent reaction is described in which five organic molecules form a cyclohexane ring. Aryl aldehydes, malononitrile and acetone in the presence of a catalytic amount of sodium acetate are stereoselectively cyclized into cis-4-dicyanomethylene-2,6-diarylcyclohexane-1,1-dicarbonitriles in 30–60% yields.

Elinson M.N. , Vereshchagin A.N. , Feducovich S.K. , Zaimovskaya T.A. , Starikova Z.A. , Belyakov P.A. , Nikishin G.I.
Unexpected stereoselective sodium acetate catalyzed multicomponent cyclization of aryl aldehydes, malononitrile and acetone into cis-4-dicyanomethylene-2,6-diarylcyclohexane-1,1-dicarbonitriles
Tetrahedron Letters. 2007. V.48. N38. P.6614-6619. DOI: 10.1016/j.tetlet.2007.07.119 WOS Scopus OpenAlex

Web of science:	WOS:000249627500002
Scopus:	2-s2.0-34548023093
OpenAlex:	W2950105896

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OpenAlex	29
Scopus	31
Web of science	34