Antimicrobial screening of a historical collection of over 140 000 small molecules

Antimicrobial screening of a historical collection of over 140 000 small molecules Full article

Journal

Mendeleev Communications
ISSN: 1364-551X , E-ISSN: 0959-9436

Output data

Year: 2021, Volume: 31, Number: 4, Pages: 484-487 Pages count : 4 DOI: 10.1016/j.mencom.2021.07.015

Authors

Semenov Victor V. ¹ , Raihstat Mikhail M. ¹ , Konyushkin Leonid D. ¹ , Semenov Roman V. ¹ , Blaskovich Mark A.T. ² , Zuegg Johannes ² , Elliott Alysha G. ² , Hansford Karl A. ² , Cooper Matthew A. ²

Affiliations

1	N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991,Moscow, Russian Federation
2	Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia

Most of the chemical compound collection (currently about 200 000), assembled at the N. D. Zelinsky Institute of Organic Chemistry over the past 30 years, has been screened for antimicrobial activity against five ESKAPE pathogens and two fungi at the University of Queensland on a charitable basis. A total of 2517 active molecules (MIC ≤ 32 μg ml–1) were found, of which about 10% are active at very low concentrations (MIC ≤ 1 μg ml–1). Structures of 142 012 compounds and experimental data on their antimicrobial activity are publicly available through the demo version of the CheD software and the public database of the Community for Open Antimicrobial Drug Discovery.

Semenov V.V. , Raihstat M.M. , Konyushkin L.D. , Semenov R.V. , Blaskovich M.A.T. , Zuegg J. , Elliott A.G. , Hansford K.A. , Cooper M.A.
Antimicrobial screening of a historical collection of over 140 000 small molecules
Mendeleev Communications. 2021. V.31. N4. P.484-487. DOI: 10.1016/j.mencom.2021.07.015 WOS Scopus OpenAlex

Web of science:	WOS:000687981200015
Scopus:	2-s2.0-85113619482
OpenAlex:	W3194713890

DB	Citing
OpenAlex	13
Scopus	11
Web of science	10