Polyalkoxybenzenes from plant sources 2. Synthesis of isoxazoline analogs of combretastatin from natural allyl(methylenedioxy)methoxybenzenes

Polyalkoxybenzenes from plant sources 2. Synthesis of isoxazoline analogs of combretastatin from natural allyl(methylenedioxy)methoxybenzenes Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Вых. Данные

Год: 2007, Том: 56, Номер: 12, Страницы: 2460-2465 Страниц : 6 DOI: 10.1007/s11172-007-0391-7

Авторы

Tsyganov D.V. ¹ , Yakubov A.P. ¹ , Konyushkin L.D. ¹ , Firgang S.I. ¹ , Semenov V.V. ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

A series of analogs of the natural mitostatic agent combretastatin were synthesized by the reaction of nitrile oxides with natural allylbenzenes, such as myristicin, apiol, and dillapiol. The 1,3-dipolar cycloaddition reactions in allylic systems proceed regiospecifically. The reactions with trans isomers of propenylbenzenes, viz., isomyristicin, isoapiol, and isodillapiol, as dipolarophiles produce regioisomers.

Tsyganov D.V. , Yakubov A.P. , Konyushkin L.D. , Firgang S.I. , Semenov V.V.
Polyalkoxybenzenes from plant sources 2. Synthesis of isoxazoline analogs of combretastatin from natural allyl(methylenedioxy)methoxybenzenes
Russian Chemical Bulletin. 2007. V.56. N12. P.2460-2465. DOI: 10.1007/s11172-007-0391-7 WOS Scopus OpenAlex

≡ Web of science:	WOS:000257888700017
≡ Scopus:	2-s2.0-52649172676
≡ OpenAlex:	W1970074359