1,2-Bis(methylamino)ethane-1,2-diol dihydrochloride as a new precursor of 1,2,1",2"-tetramethyl-3,3"-bidiaziridine

1,2-Bis(methylamino)ethane-1,2-diol dihydrochloride as a new precursor of 1,2,1",2"-tetramethyl-3,3"-bidiaziridine Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Вых. Данные

Год: 2004, Том: 53, Номер: 3, Страницы: 641-646 Страниц : 6 DOI: 10.1023/b:rucb.0000035650.08227.36

Авторы

Petukhova V.Yu. ¹ , Makhova N.N. ¹ , Ananikov V.P. ¹ , Strelenko Yu.A. ¹ , Fedyanin I.V. ²

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
2	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russian Federation

Using the synthesis of 1,2-bis(methylamino)ethane-1,2-diol dihydrochloride (5) as an example, it was demonstrated that aliphatic α-aminocarbinols can be stabilized as hydrochlorides. The reaction of compound 5 with N-chloromethylamine in CHCl3 in the presence of K2CO3 afforded 1,2,1",2"-tetramethyl-3,3"-bidiaziridine as a mixture of diastereomers (a racemate and a meso form). The meso form was isolated in the individual state and its structure was established by X-ray diffraction analysis. The kinetics of inversional epimerization was studied.

Petukhova V.Y. , Makhova N.N. , Ananikov V.P. , Strelenko Y.A. , Fedyanin I.V.
1,2-Bis(methylamino)ethane-1,2-diol dihydrochloride as a new precursor of 1,2,1",2"-tetramethyl-3,3"-bidiaziridine
Russian Chemical Bulletin. 2004. V.53. N3. P.641-646. DOI: 10.1023/b:rucb.0000035650.08227.36 Scopus OpenAlex

Scopus:	2-s2.0-4043101130
OpenAlex:	W2953135286

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