Green on-water multicomponent approach for the synthesis of pyrrolo[2,3-d]pyrimidines

Green on-water multicomponent approach for the synthesis of pyrrolo[2,3-d]pyrimidines Full article

Journal

Tetrahedron Letters
ISSN: 0040-4039 , E-ISSN: 1873-3581

Output data

Year: 2021, Volume: 81, Article number : 153336, Pages count : DOI: 10.1016/j.tetlet.2021.153336

Authors

Ryzhkova Yuliya E. ¹ , Fakhrutdinov Artem N. ¹ , Elinson Michail N. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian academy of sciences, Leninsky pr. 47, Moscow, 119991, Russian Federation

A novel green on-water multicomponent approach for the synthesis of pyrrolo[2,3-d]pyrimidines was developed based on the multicomponent reaction of arylglyoxals, barbituric acids, and 6-aminopyrimidine-2,4(1H,3H)-diones. The studied non-catalytic process includes Knoevenagel condensation, Michael addition, and intramolecular heterocyclization. The structure of one of the pyrrolo[2,3-d]pyrimidine derivatives was determined by 2D NMR spectroscopy.

Ryzhkova Y.E. , Fakhrutdinov A.N. , Elinson M.N.
Green on-water multicomponent approach for the synthesis of pyrrolo[2,3-d]pyrimidines
Tetrahedron Letters. 2021. V.81. 153336 . DOI: 10.1016/j.tetlet.2021.153336 WOS Scopus OpenAlex

≡ Web of science:	WOS:000709773200007
≡ Scopus:	2-s2.0-85113855973
≡ OpenAlex:	W3195191233