Synthesis of functionalized organophosphorus analogs of β-phenylalanine | Sciact

Synthesis of functionalized organophosphorus analogs of β-phenylalanine Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Вых. Данные

Год: 2024, Том: 73, Номер: 5, Страницы: 1374-1385 Страниц : 12 DOI: 10.1007/s11172-024-4255-1

Авторы

Bubnov Yu.N. ^1,3 , Prishchenko A.A. ² , Livantsov M.V. ² , Novikova O.P. ² , Livantsova L.I. ² , Baranin S.V. ¹

Организации

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2	Chemical Department, M. V. Lomonosov Moscow State University, Build. 3, 1 Leninskiye Gory, 119991, Moscow, Russian Federation
3	A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Build. 1, 28 ul. Vavilova, 119991 Moscow, Russian Federation

A convenient synthesis of organophosphorus analogs of β-phenylalanine containing functionalized 2-phenylethylphosphonous and 2-phenylethylphosphinic acid moieties has been developed. The radical addition of bis(trimethylsiloxy)phosphine to styrene, trimethylsilyl cinnamate, or arylacetylenes proceeds regioselectively to give a variety of substituted 2-phenylethylphosphonites, and the subsequent functionalization affords various derivatives of the target acids. The resulting compounds are of interest as promising biologically active compounds and water-soluble ligands.

Bubnov Y.N. , Prishchenko A.A. , Livantsov M.V. , Novikova O.P. , Livantsova L.I. , Baranin S.V.
Synthesis of functionalized organophosphorus analogs of β-phenylalanine
Russian Chemical Bulletin. 2024. V.73. N5. P.1374-1385. DOI: 10.1007/s11172-024-4255-1 WOS Scopus OpenAlex

≡ Web of science:	WOS:001252371600019
≡ Scopus:	2-s2.0-85196560917
≡ OpenAlex:	W4399897712