N-Acetonylnitropyrazolecarboxylic acids in the selective synthesis of N-acetonyl-3-R-5-nitropyrazolyl-1,2,4-oxadiazoles

N-Acetonylnitropyrazolecarboxylic acids in the selective synthesis of N-acetonyl-3-R-5-nitropyrazolyl-1,2,4-oxadiazoles Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2024, Volume: 73, Number: 5, Pages: 1362-1373 Pages count : 12 DOI: 10.1007/s11172-024-4254-2

Authors

Khoranyan T.E. ¹ , Gushchina P.K. ¹ , Suponitsky K.Yu. ¹ , Dalinger I.L. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

Alkylation of isomeric methyl nitropyrazolecarboxylates with bromoacetone followed by acid hydrolysis gave new N-acetonylnitropyrazolecarboxylic acids. A selective synthesis of 3-R-5-(N-acetonylnitropyrazolyl)-1,2,4-oxadiazoles based on the reaction of nitropyrazolecarboxylic acid chlorides with isomeric amidoximes of nitropyrazoles and aminofurazan was developed. The possibility to introduce the second N-acetonyl group into di(nitropyrazolyl)-1,2,4-oxadiazoles was studied.

Khoranyan T.E. , Gushchina P.K. , Suponitsky K.Y. , Dalinger I.L.
N-Acetonylnitropyrazolecarboxylic acids in the selective synthesis of N-acetonyl-3-R-5-nitropyrazolyl-1,2,4-oxadiazoles
Russian Chemical Bulletin. 2024. V.73. N5. P.1362-1373. DOI: 10.1007/s11172-024-4254-2 WOS Scopus OpenAlex

≡ Web of science:	WOS:001252371600024
≡ Scopus:	2-s2.0-85196627245
≡ OpenAlex:	W4399897788