The synthesis of furazano- and thiadiazolopyrazine steroids and their antiproliferative activity

The synthesis of furazano- and thiadiazolopyrazine steroids and their antiproliferative activity Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2024, Volume: 60, Number: 3-4, Pages: 205-208 Pages count : 4 DOI: 10.1007/s10593-024-03319-x

Authors

Vorontsova Svetlana K. ¹ , Scherbakov Alexander M. ² , Minyaev Mikhail E. ¹ , Menchikov Leonid G. ¹ , Zavarzin Igor V. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave, Moscow, 119991, Russia
2	Department of Experimental Tumor Biology, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, 24, Build. 15 Kashirskoe highway, Moscow, 115522, Russia

An effective method for the synthesis of heterocyclic steroids with the [1,2,5]oxadiazolo[3,4-b]pyrazine and [1,2,5]thiadiazolo[3,4-b]-pyrazine fragments was developed. The structure of the products was confirmed by X-ray structural analysis. The resulting compounds showed high antiproliferative activity against breast (MCF7) and prostate (22Rv1) cancer cells, which was not inferior to that of cisplatin and abiraterone acetate.

Vorontsova S.K. , Scherbakov A.M. , Minyaev M.E. , Menchikov L.G. , Zavarzin I.V.
The synthesis of furazano- and thiadiazolopyrazine steroids and their antiproliferative activity
Chemistry of Heterocyclic Compounds. 2024. V.60. N3-4. P.205-208. DOI: 10.1007/s10593-024-03319-x WOS Scopus OpenAlex

≡ Web of science:	WOS:001238182000002
≡ Scopus:	2-s2.0-85195171584
≡ OpenAlex:	W4399298862