Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives

Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives Full article

Journal

Chemistry of Heterocyclic Compounds
ISSN: 1573-8353 , E-ISSN: 0009-3122

Output data

Year: 2021, Volume: 57, Number: 7-8, Pages: 828-836 Pages count : 9 DOI: 10.1007/s10593-021-02987-3

Authors

Shkineva Tatyana K. ¹ , Vatsadze Irina A. ¹ , Khoranyan Tigran E. ¹ , Lipilin Dmitry L. ¹ , Pivkina Alla N. ² , Dalinger Igor L. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
2	N. N. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

A method was developed for the synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazoles by acylation of amidoximes with acyl chlorides, followed by cyclization of pyrazolyl-O-acylamidoximes into the respective oxadiazoles. Nitration of these products was studied, in combination with nucleophilic substitution reactions in the obtained nitro derivatives.

Shkineva T.K. , Vatsadze I.A. , Khoranyan T.E. , Lipilin D.L. , Pivkina A.N. , Dalinger I.L.
Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives
Chemistry of Heterocyclic Compounds. 2021. V.57. N7-8. P.828-836. DOI: 10.1007/s10593-021-02987-3 WOS Scopus OpenAlex

≡ Web of science:	WOS:000693902100004
≡ Scopus:	2-s2.0-85114988940
≡ OpenAlex:	W3198746382