Nitro-substituted 2-aryl-[1,2,4]triazolo[1,5-a]azines in the reactions with C-nucleophiles

Nitro-substituted 2-aryl-[1,2,4]triazolo[1,5-a]azines in the reactions with C-nucleophiles Full article

Journal

Russian Chemical Bulletin
ISSN: 1573-9171 , E-ISSN: 1066-5285

Output data

Year: 2024, Volume: 73, Number: 5, Pages: 1334-1341 Pages count : 8 DOI: 10.1007/s11172-024-4251-5

Authors

Bastrakov M.A. ¹ , Kruchinin A.A. ¹ , Kolyadina S.A. ¹ , Starosotnikov A.M. ¹

Affiliations

1	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

Synthesis of nitro-substituted [1,2,4]triazolo[1,5-a]pyrimidines based on oxidative cyclization of the corresponding nitropyrimidinyl hydrazones of aromatic aldehydes was developed. The reactions of 2-aryl-6-nitro-[1,2,4]triazolo[1,5-a]pyrimidines and their structural analogs (2-aryl-6,8-dinitro-[1,2,4]triazolo[1,5-a]pyridines) with different C-nucleophiles were studied. Nucleophilic addition to the pyridine and pyrimidine rings carried out under mild base-free conditions gave new stable 1.5-dihydro-[1,2,4]triazolo [1,5-a]-pyridines and 1.5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidines in the yields up to 94%.

Bastrakov M.A. , Kruchinin A.A. , Kolyadina S.A. , Starosotnikov A.M.
Nitro-substituted 2-aryl-[1,2,4]triazolo[1,5-a]azines in the reactions with C-nucleophiles
Russian Chemical Bulletin. 2024. V.73. N5. P.1334-1341. DOI: 10.1007/s11172-024-4251-5 WOS Scopus OpenAlex

Web of science:	WOS:001252371600034
Scopus:	2-s2.0-85196650263
OpenAlex:	W4399899271

DB	Citing
OpenAlex	4
Scopus	4
Web of science	4