Sciact
  • EN
  • RU

Synthesis, structural characterization and cytotoxic activity of heterocyclic compounds containing the furoxan ring Научная публикация

Журнал Arkivoc
ISSN: 1551-7012 , E-ISSN: 1551-7004
Вых. Данные Год: 2017, Том: 2017, Номер: 3, Страницы: 250-268 Страниц : 19 DOI: 10.24820/ark.5550190.p010.229
Авторы Kulikov Alexander S. 1 , Larin Alexander A. 1 , Fershtat Leonid L. 1 , Anikina Lada V. 2 , Pukhov Sergey A. 2 , Klochkov Sergey G. 2 , Struchkova Marina I. 1 , Romanova Anna A. 3 , Ananyev Ivan V. 3 , Makhova Nina N. 1
Организации
1 Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation
2 Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Moscow region, Russian Federation
3 A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova str., 119991 Moscow, Russian Federation

Реферат: A direct approach to the synthesis of previously unknown 1H-1,2,3-triazolylfuroxans, involving nucleophilic substitution of the nitro group in nitrofuroxans followed by catalytic [3+2] cycloaddition of intermediate azidofuroxans to 1,3-ketoesters, is reported. The scope of the triazolylfuroxans was additionally diversified through a number of transformations of the functional groups attached to the 1,2,3-triazole ring. The cytotoxic activity of the newly synthesized triazolylfuroxans and of previously reported hetarylfuroxans was studied. The NO-donor capability of selected synthesized hetarylfuroxans was measured by the Griess reaction using a spectrophotometric technique.
Библиографическая ссылка: Kulikov A.S. , Larin A.A. , Fershtat L.L. , Anikina L.V. , Pukhov S.A. , Klochkov S.G. , Struchkova M.I. , Romanova A.A. , Ananyev I.V. , Makhova N.N.
Synthesis, structural characterization and cytotoxic activity of heterocyclic compounds containing the furoxan ring
Arkivoc. 2017. V.2017. N3. P.250-268. DOI: 10.24820/ark.5550190.p010.229 WOS Scopus OpenAlex
Идентификаторы БД:
Web of science: WOS:000408556800022
Scopus: 2-s2.0-85027978371
OpenAlex: W2773010475
Цитирование в БД:
БД Цитирований
OpenAlex 26
Scopus 26
Web of science 31
Альметрики: